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To support maximal growth and metabolic function of major
2022-02-25
To support maximal growth and metabolic function of major organs, glucose and actin inhibitor are essential. We assessed the plasma levels of glucose and amino acids in LBW and NBW piglets at birth and at day 7 postpartum. Blood glucose levels were influenced by birthweight and age. In this study,
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Cortisol targets many organs and
2022-02-25
Cortisol targets many organs and tissues and has certain effects on metabolism, including promoting glycolysis. It can cross the blood spectinomycin barrier and act centrally to regulate HPA axis activity by activating negative feedback mechanisms effectively, cortisol inhibits its own production (
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Ghrelin receptors in non mammals are reportedly more complic
2022-02-25
Ghrelin receptors in non-mammals are reportedly more “complicated/complex and diverse” than in mammals, having additional paralogs and splice variants (Kaiya et al., 2014). Several teleost fish GHS-Rs have been identified; however, functional characterization has been conducted in only a few (see, K
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br Materials and methods Manganese chloride MnCl H O
2022-02-25
Materials and methods Manganese chloride (MnCl2·4H2O), glutamate, glutamine, Lucifer Yellow, polyclonal anti-GFAP and MTT assay kits were purchased from Sigma Chemical Co. (St. Louis, MO). Dulbecco's Modified Eagle's Medium-F12 (DMEM-F12) with Earle's salts, foetal bovine serum, penicillin, and s
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The expression and localization of Cx Cx and
2022-02-25
The expression and localization of Cx43, Cx46 and Cx50 in the anterior pituitary vary with physiological activities and with various conditions associated with both natural and pathological changes in hormone secretion. Anterior pituitary Cx43 and Cx50 levels increase and exhibit a more widespread d
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In summary the SAR of a series
2022-02-24
In summary, the SAR of a series of phenylpropanoic acid-free fatty checkpoint pathway receptor agonists is described which resulted in the identification of potent FFA4 agonists. The superior pharmacokinetic properties of compound led to its selection as an in vivo tool compound which afforded rob
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br Materials and methods br Results br
2022-02-24
Materials and methods Results Discussion FFAR4 is a G-protein coupled free fatty signaling receptor that has been reported to be expressed in osteoclasts and osteoblasts [18]. In this study the role of FFAR4 on the effects of different classes of UFAs, the ω−6 PUFA, AA, the ω−3 PUFAs, DHA
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Freinkel first reported in the
2022-02-24
Freinkel first reported in the late 1960s that maternal hypertriglyceridemia benefits the fetus during starvation by increasing maternal consumption of triglyceride for ketone body synthesis giving the basis for “accelerated starvation” theory [4,5]. This maternal metabolic reprogramming during peri
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In conclusion studies of the
2022-02-24
In conclusion, studies of the regulation of the HO-1/BVR/CO pathway by selective pharmacological approaches may lead to the discovery of novel compounds for the treatment of diverse diseases. Recent results validate the use of advances in targeting HO-1 in various vascular diseases. However, there a
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br Conflict of interest br Introduction
2022-02-24
Conflict of interest Introduction Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, most often in the pelvic peritoneum and ovaries. This disorder affects an estimated 10% of women in the reproductive age group and is basically an estrogen-dependent
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Lastly certain populations of immune cells may be Hh
2022-02-24
Lastly, certain populations of immune cells may be Hh responsive. Although PC have not been demonstrated in healthy liver-resident macrophages or lymphocytes, macrophages in injured livers have been shown to produce Hh ligands[58], [100], [101] and treating liver-derived macrophages with neutralisin
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br Structural studies of the cyclase catalytic domains br
2022-02-24
Structural studies of the cyclase catalytic domains Structural determinants for catalytic activity The structure of the active αβGCcat structure has remained elusive. However, several studies have suggested how specific structural elements are involved in αβGCcat transitioning from the open in
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GPR belongs to the G protein coupled receptor family
2022-02-24
GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty BOP reagent (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone marrow
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For several parasites of veterinary importance there is a gr
2022-02-23
For several parasites of veterinary importance, there is a growing body of evidence that resistance to ML is, at least in part, mediated by ABC transporters (P-glycoproteins) (Whittaker et al., 2017). P-glycoproteins (Pgps) are members of the ATP-binding cassette transporter family that are well kno
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Accordingly it is tempting to speculate
2022-02-23
Accordingly, it is tempting to speculate that the maintenance of a stimulus representation in the A2 state for a short period of time after the presentation of a specific stimulus (i.e. self-generated priming) may rely upon GluR-A-dependent synaptic plasticity. If this were the case, GluR-A CC-115
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