• In vasculature NADPH oxidases NOXs are the main sources of

  2020-05-21

  

  In vasculature, NADPH oxidases (NOXs) are the main sources of O2− generation that involve in the transfer of electrons to molecular oxygen. Endothelin-1 [25] and thromboxane A2 [26] were reported to induce eNOS uncoupling via upregulation of NOXs. Additionally, inhibition of p47 phox, a subunit of N

• Nrf and HO are key

  2020-05-21

  

  Nrf2 and HO-1 are key factors in the regulation of oxidative stress in the body. Research has shown that KLF2 can activate Nrf2 and HO-1 [14]. To investigate the mechanisms by which KLF2 regulates eNOS uncoupling and oxidative stress, Nrf2 was inhibited or HO-1 was knocked down in KLF2 overexpressin

• To study the effect of DDR inhibition by

  2020-05-21

  

  To study the effect of DDR inhibition by imatinib, nilotinib and dasatinib in a cellular environment we generated DDR1 and DDR2 expressing HEK293 cell lines by stable transfection. Of the five DDR1 splice variants we focused on the 1b variant whose over-expression has been associated with pulmonary

• Why are Tfh cell dynamics so fundamentally different

  2020-05-21

  

  Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC SP2509 must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest helper capacit

• One architecture termed closed has been visualized at near

  2020-05-21

  

  One architecture, termed closed, has been visualized at near-atomic resolution in cryo-EM maps of recombinant complexes that superimpose with earlier lower-resolution EM data obtained for APC/CCDC20–MCC purified from HeLa GSK126 arrested during the mitotic checkpoint (Figure 4E) 38, 48, 51. Here, M

• br Materials and methods br Results br Discussion Tuberculos

  2020-05-21

  

  Materials and methods Results Discussion Tuberculosis is caused by the mycobacterium M. tuberculosis, a pathogen able to survive in the hostile conditions through sophisticated defence mechanisms. In an attempt to clarify some aspects of the M. tuberculosis defence mechanisms, we have inves

• An AmDH is engineered by mutating two

  2020-05-21

  

  An AmDH is engineered by mutating two conserved amino Mirin residues in the active site of an amino acid dehydrogenase (AADH). Starting from the leucine dehydrogenase (LeuDH) from Bacillus stearothermophilus, substituting a serine and leucine at the K68 and N261 positions, respectively, resulted in

• Studies on the external dehydrogenases of

  2020-05-21

  

  Studies on the external dehydrogenases of N. crassa have shown that the NDE1 protein is a Ca2+-dependent external NADPH dehydrogenase, while NDE2 is characterized as a dehydrogenase oxidizing both cytosolic substrates (external NADH and/or NADPH) (Carneiro et al., 2004, Melo et al., 2001). All three

• br Introduction Cardiovascular disease continues to be the

  2020-05-21

  

  Introduction Cardiovascular disease continues to be the leading cause of death in developed countries. Atherosclerosis, a chronic inflammatory cardiovascular disease, is characterized by the progressive buildup of oxidized low density lipoproteins in the arterial walls (Ross, 1999). In the develo

• In conclusion our work led to the characterization

  2020-05-21

  

  In conclusion, our work led to the characterization of some signalling events of the CysLT1 receptor variants, at several levels, and showed that a punctual serine mutation could alter the response of receptors to cysLTs. Although atopy is a complex phenotype implicating different cell types, mediat

• To be a qualified non specific

  2020-05-21

  

  To be a qualified non-specific CYP inhibitor used as an in vitro or in vivo screening tool to distinguish CYP involvement in the overall metabolism, a complete inhibition of the entire metabolism catalyzed by CYPs in a simple experiment is desired. Based on our results, 100 μM atipamezole can comple

• Importantly our in vivo data fit to the in

  2020-05-19

  

  Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 CPI-455 sale levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 2016).

• br Methods br Results br

  2020-05-19

  

  Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide 2-Deoxycytidine dinucleotide phosphate (NADPH) oxidase complex, xanthine oxidase

• In principle in vitro techniques for assessing enzyme induct

  2020-05-19

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized Cy5.5 hydrazide lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant

• Following DEX exposure the levels of CYP A protein

  2020-05-19

  

  Following DEX exposure, the levels of CYP1A1 protein and activity remained unchanged, as seen in our previous in vitro study (Burkina et al., 2013). Dasmahapatra and Lee (1993) reported that 3.9μgL−1 DEX, similar to our highest tested concentration, did not change CYP1A1 protein content. An increase

15687 records 835/1046 page Previous Next First page 上5页 831832833834835 下5页 Last page